It is anticipated that an in-depth study on the HTL parameters, optimization of the CO-HTL process, and techno-economic assessment will provide an outlook scenario of the industrial-scale process for high biofuels production capacity. The project will respond to the Renewable Energy Directive (RED, 2009/28/EC) targeting -20-20-20 by 2020: 20% reduction in greenhouse gas emissions; 20% increase in energy efficiency; 20% of the EU’s energy consumption to be from renewable sources. Hence, CoBiol will have a positive and pioneering impact in bringing together Europe’s knowledge-based economy and society towards sustainable and green transportation.